Second Cycle Programmes    (Master's Degree)
Master (with thesis) - Institute of Health Sciences - Pharmaceutical Chemistry - Drug Metabolism
General Description  |  Key Learning Outcomes  |  Course Structure Diagram with Credits
General Description ^
History
The peculiar activity domain of drug metabolism master of science (MSc) program comprises chemical and enzymatic basis of dug metabolism, medicinal chemistry of active drug ingredients and their metabolites, characterization and analysis of the metabolites. In order to educate well-qualified specialists and researchers with sufficient knowledge on the topics mentioned above the MSc program in drug metabolism, that has been appertained to Institute of Health Sciences, was established in academic year 1994-1995.
Qualification Awarded
By the achievement of the program the title ‘’master of science’’ is assumed.
Specific Admission Requirements
The students have to comply with the regulations of postgraduate education and training. Bachelor degree in Pharmacy (4 or 5 years education) or Chemistry is required. The students have to pass the digital section of the‘’Academic Staff and the Graduate Entry Examination’’ with the score equivalent to or greater than 60%. The students have to succeed in scientific assessment and interview.
Specific Arrangements For Recognition Of Prior Learning (Formal, Non-Formal and Informal)
Bachelor degree in Pharmacy (4 or 5 years education) or Chemistry is required.
Qualification Requirements and Regulations
The students have to succeed in all courses of the master program and master thesis completion exam applied by an academic assessment committee.
Profile of The Programme
The students are taught basic topics in pharmaceutical chemistry, chemical and enzymatic aspects of drug metabolism, medicinal chemistry and analysis of drug substances and their metabolites and they are sophisticated as being a researcher in a project.
Occupational Profiles of Graduates With Examples
Carries on his/her academic career in state and private universities, finds an employment in drug industry (research and development, quality control, production, regulatory affairs), works for national or international research centers as a specialist or project manager.
Access to Further Studies
By the achievement of drug metabolism master program and ALES examination (with the examination mark greater than or equal to the mark declared by the institute); the graduate, who has adequate competence on preferred foreign languages (especially English), can apply for the doctorate programs concerning his/her master program or other multidisciplinary programs. If the student succeeds in scientific assessment and interview he/she can attend the doctorate program
Examination Regulations, Assessment and Grading
The graduation score is composed of mid-term assessments (mid-term exam, housework, project) by the ratio of 40% and final assessments (final exam, housework, project) by the ratio of 60%. The student has to succeed in master thesis completion exam applied by an academic assessment committee.
Graduation Requirements
The program comprises at least 21 local credits from at least 7 lessons, 1 seminar course, master of science (MSc) thesis completion exam. The MSc program includes compulsory and elective courses with the total 60 AKTS credits. Together with mid-term and final exams; education activities as report preparation and homeworks, quizes, presentations and demonstrative works, participation in projects could be taken into consideration by means of performance appraisal of the studuent. The students have to pass exams of each course with the score equivalent to or greater than 65%. If the student completes a course with failure he/she can register at the same course for a second time or register at different MSc courses approved by his/her advisor. The student can apply at most two undergraduate courses that had not been applied during the student’s undergraduate education. The seminar course and thesis work have no credits in the local credit system and have been depicted as successfull or failure in the transcript. The student has to apply for the course that regulates his/her work on the thesis as from the beginning of third semester at the latest. The student has to write the results of his/her MSc thesis work in accordance with the concerned institute’s guidebook that denotes the rules of wording and also the student has to present his/her MSc thesis orally in the presence of an academic assessment committee. Following this presentation the academic assessment committee take a decision by simple majority on the thesis either acceptance or refusal and also the academic assessment committee has the right to postulate a correction within context of the thesis.If the academic assessment committee claim for correction the student has to review his/her thesis and prepare an adequate version during six months and the student has to present his/her MSc thesis again, in the presence of the same academic assessment committee. If the academic assessment committee refuses the reviewed thesis the student’s subscription will be abrogated
Mode of Study (Full-Time, Part-Time, E-Learning )
Full-Time
Address, Programme Director or Equivalent
Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry Tıbbiye Street No: 49 Haydarpaşa 34668 İSTANBUL Prof.Dr. İlkay Küçükgüzel (Tel : 0216 349 12 16 – e-mail : ikucukguzel@marmara.edu.tr
Facilities
The Department is well equipped with modern research instrumentation and equipment in the areas of organic synthesis, spectroscopic (UV and IR Spectrophotometer) and chromatographic (liquid chromatograph with PDA detector) analysis, drug metabolism and literature research (permanent internet, ScienceDirect and WOS database Access). Marmara University Scientific Research Projects Commission supports master thesis.
Key Learning Outcomes ^
1 A succesful graduate of this program : has theoretical knowledge and practical skills about chemical nomenclature of drug substances and metabolites, synthesis upon need, purification, spectral characterization.
2 has theoretical knowledge and ability to make interpretations about organic reaction mechanisms required for a better understanding of medicinal chemistry and biotransformation.
3 has knowledge and ability to make interpretation about potential metabolic routes and biotransformation mechanisms in relation to chemical structure of drug molecules.
4 has the knowledge about identification of potential metabolites resulting biotransformation of drugs, pharmacological and toxicological consequences of these reactions and development of prodrugs.
5 knows the enzymes involved in drug metabolism and has knowledge about experimental models and drug metabolism techniques to determine the contribution of these enzymes.
6 has knowledge and practical skills related to chromatographic and spectral techniques required for isolation and identification of drugs and metabolites from biological matrices.
7 has knowledge about drug structure - metabolic reaction relationships and mechanisms for the formation of metabolites.
8 can make literature search and reach to the sources about drug metabolism and related topics; makes interpretation and perform the required experimental techniques by applying these data.
9 ensures use of the knowledge produced by drug metabolism research in medicinal chemistry field, for development of novel drug molecules and for drug safety.
10 reachs the level to be involved in a research or project in the above mentioned fields, under supervision of an advisor.
11 is an eligible individual for team work in a group of researchers from different disciplines of pharmaceutical field.
12 keeps his/her knowledge about developments up to date by following the domestic and international sources.
13 elicits consultative knowledge on drug metabolism to health proffessionals.
Course Structure Diagram with Credits ^
T : Theoretical P: Practice
No Course Unit Code Course Unit Title Type of Course T P ECTS
1 FMK719 Chemical Aspects of Drug Metabolism Compulsory 2 2 6
2 FMK721 Metabolite Isolation and Identification Methods Compulsory 2 2 6
3 FMK-S1,2,3-YL Elective - 1-2-3 Elective 9 0 18
Total 13 4 30
No Course Unit Code Course Unit Title Type of Course T P ECTS
1 FMK700 Seminar Compulsory 0 2 5
2 FMK-S4..7-YL Seçimlik Ders - 4..7 Elective 12 0 24
Total 12 2 29
No Course Unit Code Course Unit Title Type of Course T P ECTS
1 Thesis Compulsory 60

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