Second Cycle - Institute of Health Sciences - Basic Medicine Science - Oral Biology
Y : Year of Study S : Semester
Course Unit Code Course Unit Title Type of Course Y S ECTS
ORB717 Medical Genetic I Compulsory 1 1 12
Objectives of the Course
The aim of this course is to give information about the molecular systems of the cell and to have hypothesis about molecular diseases.
Learning Outcomes
1 Can look up to the general pathways of the cell at the molecular level
2 Has information about personalized medicine
3 Has information about the reasons of hereditary diseases and how they are transmitted
4 Learns the pathways of DNA and RNA
5 Gains knowledge about he structure of nucleic acids
Mode of Delivery
Formal Education
Recommended Optional Programme Components
None
Course Contents
Introduction to medical genetics; DNA and chromosome organization; Replication, transcription and translation; Cell cycle and divisions; Mutation and polymorphisms; Mutation repair systems; Spermatogenesis and Oogenesis, Fertilization; Hereditary types; Molecular techniques used in molecular genetics; Genetics of oral diseases; Cancer, protooncogenes, tumor suppressor genes;Molecular basis of oral premalignancies and malignancies; Pharmacogenomics and pharmacogenetics
Weekly Detailed Course Contents
Week Theoretical Practice Laboratory
1 Introduction to medical genetics Microscope and examination of human cheek cells
2 DNA and chromosome organization Microscope and examination of human cheek cells
3 Replication, transcription and translation Microscope and examination of human cheek cells
4 Cell cycle and divisions DNA isolation, protein precipitation
5 Mutation and polymorphisms DNA isolation, protein precipitation
6 Mutation repair systems DNA isolation, protein precipitation
7 Spermatogenesis and Oogenesis, Fertilization Agarose gel elechtrophoresis
8 Midterm exam Midterm exam
9 Hereditary types Agarose gel elechtrophoresis
10 Molecular techniques used in molecular genetics Agarose gel elechtrophoresis
11 Genetics of oral diseases I Polymerase chain reaction
12 Genetics of oral diseases II Polymerase chain reaction
13 Cancer, protooncogenes, tumor suppressor genes Polymerase chain reaction
14 Molecular basis of oral premalignancies and malignancies General review
15 Pharmacogenomics and pharmacogenetics General review
16 Study week Study week
17 Final exam Final exam
Recommended or Required Reading
Human molecular biology, Richard Epstein, Cambridge University Press, 2012
Human Genetics, Bruce Korf, Blackwell Publishing, 2009
The cell, Geoffrey Cooper, Robert Hausman, ASM press, 2004
Human Molecular Genetics, Tom Strachan, Andrew Read, Garland science 2004
Planned Learning Activities and Teaching Methods
Lectures, Discussion, Question-Answer, Brain storming
Assessment
AssessmentQuantityWeight
Term (or Year) Learning Activities40
End Of Term (or Year) Learning Activities60
Total100
Term (or Year) Learning ActivitiesQuantityWeight
Midterm Exam1100
Total100
End Of Term (or Year) Learning ActivitiesQuantityWeight
Final Exam1100
Total100
Language of Instruction
Language Codes
Work Placement(s)
None
Workload Calculation
Activities Number Time (hours) Total Work Load (hours)
Theoretical 14 2 28
Applied 14 4 56
Pre Class Self Study 14 3 42
Post Class Self Study 14 3 42
Post Application Self Study 14 3 42
Midterm Preparation 1 15 15
Final Preparation 1 15 15
Home Work 2 15 30
Seminar 2 15 30
Total 76 75 300
Contribution of Learning Outcomes to Programme Outcomes
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LO 100000000000000000

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